TAMP-Mediated Gemcitabine Lowers Systemic Exposure vs IV Delivery in Locally Advanced Pancreatic Cancer

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A pharmacokinetic sub-study of the phase 3 TIGeR-PaC trial shows TAMP-delivered gemcitabine significantly lowers systemic exposure compared to standard IV delivery in locally advanced pancreatic cancer.

A pharmacokinetic sub-study of the phase 3 TIGeR-PaC trial found that intra-arterial gemcitabine delivered via RenovoRx’s TAMP (Trans-Arterial Micro-Perfusion) platform produced significantly lower systemic drug exposure than standard IV administration.

The analysis found that approximately half of the intra-arterial dose was extracted at the tumor site before reaching systemic circulation, suggesting the potential to reduce systemic toxicities while maintaining local efficacy.

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