A pharmacokinetic sub-study of the phase 3 TIGeR-PaC trial found that intra-arterial gemcitabine delivered via RenovoRx’s TAMP (Trans-Arterial Micro-Perfusion) platform produced significantly lower systemic drug exposure than standard IV administration.
The analysis found that approximately half of the intra-arterial dose was extracted at the tumor site before reaching systemic circulation, suggesting the potential to reduce systemic toxicities while maintaining local efficacy.