Our Science
Advancing a new approach to how cancer therapies are delivered
Chemotherapy Effectiveness Depends on Reaching the Tumor1,2
Tumor vascularity can significantly influence therapeutic delivery. Hypervascular tumors contain extensive vascular networks that facilitate drug transport. In contrast, hypovascular tumors, including many pancreatic, lung, and sarcoma tumors, have limited blood flow, which can restrict therapy penetration and create a significant barrier to treatment delivery.
Hypervascular Tumor
- Rich blood supply with vast tumor-feeder vessels
- Existing therapies can leverage vascular pathways to reach the tumor
vs
Hypovascular Tumor
- Limited blood supply with few tumor-feeder vessels
- Chemotherapy may not reach the tumor, potentially limiting treatment effectiveness
TAMP: A targeted Option To address Drug delivery Barriers3,4
- Enables delivery of chemotherapy when tumor-feeding vessels are not present
- Overcomes perfusion limitations
- Focuses therapy where it is most needed
TAMP Mechanism of Action4
Following TAMP delivery, transmission electron microscopy analysis confirmed nanoparticles within the perivascular space of the adventia (red arrows).
After vessel isolation, increase in pressure forces drug across the artery wall into the micro-vasculature and into tissue.
Take the Next Step
Your doctor will determine if TAMP is right for you and how this approach may fit within your overall treatment plan.
References
1. Maehira H, et al. Oncology Letters. 30, 579. https://doi.org/10.3892/ol.2025.15325.
2. Dewhirst M, et al. Nat Rev Cancer. 17, 738–750 (2017). https://doi.org/10.1038/nrc.2017.93
3. Hatoum H, et al. Oncologist. Volume 29, Issue 8, August 2024, Pages 690–698, https://doi.org/10.1093/oncolo/oyae178.
4. Farsad K, et al. JVIR. 2024;35(7):1043-1048.